Based upon these data, a treatment duration of 10–14 days is recommended for bismuth quadruple therapy. The aim of this study is to compare 7-day triple therapy versus 10-day sequential therapy as the first line treatment. In the last few years, a triple therapy including a levofloxacin–amoxycillin combination has been proposed for either first-line or rescue therapy regimen to cure H. pylori infection , , , , , . The eradication rate of Helicobacter pylori (H. pylori) with triple therapy which was considered as standard first-line treatment has decreased to 70–85%. Given that pantoprazole was a new drug in this field of treatment a 10-day course seemed most appropriate. Clarithromycin triple therapy consists of a PPI, clarithromycin (Biaxin), and amoxicillin or metronidazole (Flagyl) for 14 days. Therefore, H. pylori management in the clinical practice remains a challenge for the physicians. Triple Therapy Versus Quadruple Therapies in the First Line Therapy of Helicobacter Pylori Infection. This eradication was paralleled by a marked reduction in Triple Therapy and Other Treatments for H. pylori. H pylori regimens include triple therapy, sequential therapy (patient is given one treatment, followed by another), quadruple therapy, and levofloxacin-based triple therapy (TABLE 3). One of the more common treatments for H. pylori is known as triple therapy, which includes 1-2 weeks of three different medications (9, 10). In this study pantoprazole-based triple therapy eradi-cated H. pylori in 86% (per protocol) of patients. Listing a study does not mean it has been evaluated by the U.S. Federal Government. The 2012 Maastricht Consensus (an annual meeting of the European Helicobacter Study Group) reported that standard triple therapy cure rates for H. pylori are at around 70% when all research is collated. Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. Read our disclaimer for details. H. pylori therapy may be insufficient. Clarithromycin, an antibiotic ; Amoxicillin or Tinidazole, also antibiotics; A proton pump inhibitor to reduce stomach acid Standard H pylori triple therapy using two antibiotics and a proton pump inhibitor is now widely regarded as having unacceptable failure rates. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The most recent network meta-analysis of H. pylori regimens also found that 10–14 days of bismuth quadruple therapy was superior to 7 days of clarithromycin triple therapy (85 vs. 73%, RR=1.17; 95% CI=1.12–1.21) .

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