Alloway JA, Mitchell SR "Sulfasalazine neurotoxicity: a report of aseptic meningitis and a review of the literature." Poland GA, Love KR "Marked atypical lymphocytosis, hepatitis, and skin rash in sulfasalazine drug allergy." Generally, these patients had a positive ANA, anti-DNA antibody titer, and were slow acetylators of sulfonamides. [Ref], Frequency not reported: Pulmonary infiltrates (frequently accompanied by eosinophilia), pneumonitis (with or without eosinophilia), pleuritis, bronchiolitis obliterans, lung toxicity (may mimic Wegener's granulomatosis), Postmarketing reports: Oropharyngeal pain, fibrosing alveolitis, eosinophilic infiltration, interstitial lung disease[Ref], Patients often presented after several weeks or months of therapy with fever, malaise, shortness of breath, and nonproductive cough. These occur early in the treatment and affect up to a third of people. Are there any side effects? Applies to sulfasalazine: oral tablet, oral tablet enteric coated. Lack of desire 18. nausea 19. n… Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Drug Intell Clin Pharm 22 (1988): 139-42, 43. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti … Jick H, Myers MW, Dean AD "The risk of sulfasalazine- and mesalazine-associated blood disorders." You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. Am J Gastroenterol 77 (1982): 614-6, 29. Fich A, Schwartz J, Braverman D, Zifroni A, Rachmilewitz D "Sulfasalazine hepatotoxicity." 7. You may report side effects to FDA at 1-800-FDA-1088. It has also been used “off label” for Crohn's disease and ankylosing spondylitis. Common side effects include loss of appetite, nausea or vomiting, and headache. It is used to treat inflammatory bowel disease such as ulcerative colitis, proctitis or distal ulcerative colitis, and Crohn's disease. Sullivan SN "Sulfasalazine lung. Some side effects may not be reported. Am J Gastroenterol 76 (1981): 374-6, 10. It can also be used to treat other diseases such as psoriatic arthritis, Crohn's disease and ulcerative colitis. Lenka Posts: 2 ... (DMARD), it can take up to 12 weeks before you might notice any difference, but you may notice side effects before then. Although not all of these side effects may occur, if they do occur they may need medical attention. Risks and Side Effects of Sulfasalazine. In most cases of sulfasalazine-induced SLE, patients received the drug for greater than 1 year. Clin Exp Rheumatol 10 (1992): 427, 40. Arthritis Rheum 38 (1995): 573, 24. If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Mt Sinai J Med 52 (1985): 667-70, 50. J Rheumatol 15 (1988): 529-30, 21. Less common side effects included urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Mechanick JI "Coombs' positive hemolytic anemia following sulfasalazine therapy in ulcerative colitis: case reports, review, and discussion of pathogenesis." Fertility returns when the medicine is stopped. Call your doctor for medical advice about side effects. Stomach Cramps 11. Skeith KJ, Russell AS "Adverse reaction to sulfasalazine." Some of the most common sulfasalazine side effects include headache, low sperm count in men, and nausea. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Pena JM, Gonzalez-Garcia JJ, Garcia-Alegria J, Barbado FJ, Vazquez JJ "Thrombocytopenia and sulfasalazine." Sulfasalazine just didn't work at all for me unfortunately so I'm now on a combination of Sulfasalazine … Chest 81 (1982): 766-8, 60. Peppercorn MA "Sulfasalazine. Dery CL, Schwinghammer TL "Agranulocytosis associated with sulfasalazine." If you notice any other effects, check with your healthcare professional. Jullien D, Wolkenstein P, Roupie E, Roujeau JC, Revuz J "Toxic epidermal necrolysis after sulfasalazine treatment of mild psoriatic arthritis: warning on the use of sulfasalazine for a new indication." Indigestion 7. Sulfasalazine (brand names Pyralin EN, Salazopyrin EN) is a medicine - a combination of an aspirin-like anti-inflammatory component and a sulphur antibiotic-like component - used to treat rheumatoid arthritis. Sulfasalazine - side effects. Anaphylaxis was reported during postmarketing experience with the use of products containing or metabolized to mesalamine. The following side effects have been reported as hypersensitivity reactions: erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, epidermal necrolysis (Lyell's syndrome) with corneal damage, drug rash with eosinophilia and systemic symptoms (DRESS), anaphylaxis, serum sickness syndrome, pneumonitis (with or without eosinophilia), vasculitis, fibrosing alveolitis, pleuritis, pericarditis (with or without tamponade), allergic myocarditis, polyarteritis nodosa, lupus erythematosus-like syndrome, hepatitis and hepatic necrosis (with or without immune complexes), fulminant hepatitis (sometimes leading to liver transplantation), parapsoriasis varioliformis acuta (Mucha-Haberman syndrome), rhabdomyolysis, photosensitization, arthralgia, periorbital edema, conjunctival and scleral injection, alopecia, and interstitial lung disease. Dyspepsia, nausea and abdominal discomfort were the most common side-effects, … It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Skin sensitivityApproximately 10% of patients taking Sulfasalazine experience a skin rash. Carr-Locke DL "Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease." Ann Intern Med 102 (1985): 277-8, 57. You may report side effects to the FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SULFASALAZINE. Boxermom was prescribed sulfazine to address her joint pain. All drugs may cause side effects. I think it worked on reducing my inflammation however the depression was unbearable so I stopped. Commonly reported side effects of sulfasalazine include: gastric distress, headache, nausea, oligospermia, vomiting, and anorexia. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Possible side effects of 5-ASA include, nausea and vomiting, reduced sperm count and damage to red or white blood cells, or to the liver, kidneys, pancreas, nerves or hearing. I’ve been on 500mg 2x daily for nearly 4 weeks now(had to switch to delayed release tab- stomach side effects were awful) and also take Actemra self injection weekly with 20 … Wheelan KR, Cooper B, Stone MJ "Multiple haematologic abnormalities associated with sulfasalazine." Guillemin F, Aussedat R, Guerci A, Lederlin P, Trechot P, Pourel J "Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis." These occur in about one-third of the patients. J Clin Gastroenterol 14 (1992): 132-5, 33. Namias A, Bhalotra R, Donowitz M "Reversible sulfasalazine-induced granulomatous hepatitis." Cerner Multum, Inc. "UK Summary of Product Characteristics." Call your doctor for medical advice about side effects. Sulfasalazine has many more side effects than the mesalamines do. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Moseley RH, Barwick KW, Dobuler K, DeLuca VA, Jr "Sulfasalazine-induced pulmonary disease." J Pediatr 92 (1978): 450-1, 2. 6. Infertility appeared to be reversible upon drug discontinuation. Interacts with a lot of different drugs and can also cause many side effects. Gastroenterology 75 (1978): 95-9, 35. Arthritis Rheum 47 (2002): 234-41, 3. Ireland A, Jewell DP "Sulfasalazine-induced impotence: a beneficial resolution with olsalazine?." My husband takes sulfasalazine for rheumatoid arthritis and it seems to work great for his pain but it is causing crappy side effects. Available for Android and iOS devices. Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. Am J Gastroenterol 78 (1983): 493-4, 62. The use of enteric-coated preparations may decrease gastrointestinal side effects. Patients often presented with fever and sore throat. You may report side effects … These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. This medication may cause your skin and urine to turn orange-yellow. He's tried a couple of other tablets but had to stop those due to side effects such as blisters etc. "Drugs for rheumatoid arthritis." Hello there, I can't answer your question specifically but I am just starting my third week on Sulfa. Nervous tissue involvement may produce inflammation and pain along with hearing disturbances, hearing loss or lack of physical coordination. Am J Gastroenterol 79 (1984): 77, 69. It is considered by some to be a first line treatment in rheumatoid arthritis. It is usually taken four times daily after meals. Posted 5/19/2010 7:49 AM (GMT -7) Quincy, yes i had a chest x-ray before put on humira. These tend to be more successful ways of conveying the medicine to a pet then just giving him the drug directly. Kawada A, Kobayashi T, Noguchi H, Hiruma M, Ishibashi A, Marshall J "Fixed drug eruption induced by sulfasalazine." Google Scholar My husband started on sulfasalazine a week ago on two a day. CMAJ 182 (2010): 481, 72. Side effects include dry eye, decreased appetite, … Clementz GL, Dolin BJ "Sulfasalazine-induced lupus erythematosus." Clin Neuropharmacol 31 (2008): 368-71, 9. Eur J Clin Pharmacol 43 (1992): 215-8, 52. These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. Sulfasalazine is known as a disease modifying anti-rheumatic drug (DMARD).. You may report side effects … Side effects listed as postmarketing reports were reported during postmarketing experience with the use of products containing or metabolized to mesalamine. Several potentially dangerous side effects have been reported rarely with sulfasalazine. You might experience side effects with your treatment. I know you are off it, just wanted to mention for others. If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects … Check with your doctor immediately if any of the following side effects occur while taking sulfasalazine: Some side effects of sulfasalazine may occur that usually do not need medical attention. Liver biopsy has shown necrosis and infiltration with moderate number of inflammatory cells. It is used to treat rheumatoid arthritis in adults and children who are not getting enough benefit with other medicines. Trouble breathing 14. Recovery of granulocytes was generally seen within 1 to 2 weeks after drug discontinuation, and leukocyte counts and differential returned to normal in 1 to 3 weeks. Dwarakanath AD, Michael J, Allan RN "Sulphasalazine-induced renal failure." Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Int J Dermatol 47 (2008): 850-2, 4. Am J Gastroenterol 88 (1993): 1416-20, 19. Sulfasalazine is associated with few common side effects. jano437. Taffet SL, Das KM "Sulfasalazine. Drug information provided by: IBM Micromedex. Drink a full glass of water after taking sulfasalazine to protect the kidneys and to prevent kidney stones. Advertising revenue supports our not-for-profit mission. Aust N Z J Med 22 (1992): 391-2, 54. J Rheumatol 18 (1991): 634-5, 5. Am J Gastroenterol 79 (1984): 401-2, 41. I am on my 4th week of taking Sulfasalazine (at full does of 2 in the morning and 2 in the evening since Sunday). We comply with the HONcode standard for trustworthy health information -, increased sensitivity of the skin to sunlight, bluish color of the fingernails, lips, skin, palms, or nail beds, blistering, peeling, or loosening of the skin, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness, blistering, peeling, or loosening of the skin, sores, ulcers, or white spots in the mouth or on the lips, Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. Hypoglycemia has been reported rarely in patients using sulfonamides. Low Sperm Count 9. J Clin Gastroenterol 11 (1989): 711. The most common side effects are loss of appetite and nausea (feeling sick). Possible Side Effects. All symptoms resolved within 2 months after discontinuing sulfasalazine. Br Med J 320 (2000): 1113, 48. J Rheumatol 21 (1994): 748-9, 22. Contact Dermatitis 34 (1996): 155-6, 70. Serious side effects and their symptoms can include the following: Blood disorders or liver damage. 30. Sulfasalazine may cause the skin or the urine to change color. Side effects can occur earlier. Light-headedness and headaches do seem to be among the more common side effects. Posted 6/19/2014 1:40 PM (GMT -6) Gary you are wrong. 1. The most common side effects reported were anorexia, headache, nausea, vomiting, gastric distress, elevated temperature, erythema, pruritus, rash, loss of appetite, and reversible oligospermia. Hepatitis generally resolved over several weeks after therapy discontinuation, although some patients progressed to fulminant hepatic failure. Temperature 15. general body swelling 16. Arch Intern Med 140 (1980): 1122, 58. Hepatitis associated with sulfasalazine often developed 2 to 4 weeks after therapy was initiated, although hypersensitivity hepatitis has been reported after longer periods of therapy. Ann Pharmacother 27 (1993): 1052-4, 44. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Appetite loss 6. Side Effects What are the side effects of Sulfasalazine (Azulfidine)?. When taking Sulfasalazine, reported side effects are usually mild and improve in time. Diuresis has been reported rarely in patients using sulfonamides. Call your doctor or get medical help if any of these side effects or any other side effects … If you notice any other effects, check with your healthcare professional. Significant side effects occur in about 25% of people. J Rheumatol 18 (1991): 304, 20. If experienced, these tend to have a Severe expression 1. Respiratory changes generally resolved over a few weeks, however, fatal reactions involving fibrosing alveolitis have been reported. See the full sulfasalazine side effects document. Associated rash usually progressed to desquamation. Sulfasalazine may cause blood problems. Back, leg, or stomach pains 9. bleeding gums 10. bluish colour of the fingernails, lips, skin, palms, or nail beds 11. chills 12. Hello, I have been on sulfasalazine for 5 months and currently take 3000 mg a day and so far it worked well, I'm getting better slowly with no side effects. Headache 5. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Some cases of agranulocytosis were treated with colony stimulating factor, which appeared to increase the time to recovery. What Other Drugs Interact with Sulfasalazine? Sulfasalazine may cause side effects. Mut SE, Kutlu G, Ucler S, Erdal A, Inan LE "Reversible encephalopathy due to sulfasalazine." Dis Colon Rectum 29 (1986): 201-2, 25. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SULFASALAZINE. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, increased sensitivity of the skin to sunlight, bluish color of the fingernails, lips, skin, palms, or nail beds, blistering, peeling, or loosening of the skin, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness, blistering, peeling, or loosening of the skin, sores, ulcers, or white spots in the mouth or on the lips, Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. Aching of joints 2. Hill ME, Gordon C, Situnayake RD, Heath DA "Sulfasalazine induced seizures and dysphasia." Ann Intern Med 101 (1984): 377-86, 11. Int Surg 70 (1985): 271-2, 12. Common side effects of Azulfidine include gastrointestinal disturbances (nausea, vomiting, gastric distress, and loss of appetite), headache, allergic reactions, and photosensitivity (development of a rash when exposed to sunlight), … Buy Sulfasalazine Online. Gremse DA, Bancroft J, Moyer MS "Sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, and erythroid hypoplasia." Skin Discoloration 10. Norden DK, Lichtenstein GR, Williams WV "Sulfasalazine-induced myopathy." J Rheumatol 22 (1995): 191-2, 26. Less side effects than sulfasalazine. I have been struggling with a lot of relatively small issues some of which may be more to do with build up of toxicity due to mtx perhaps - I find it hard to tell which drug is doing what & then to differentiate side effects from random RA symptoms. Sulfasalazine side effects appearing from central nervous system involvement may include drowsiness, insomnia or depression, convulsions, hallucinations and meningitis. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. "Product Information. Sulfasalazine causes temporary infertility in males. Sulfasalazine can be ground up and mixed in with food or provided along with a pet treat. Haines JD, Jr "Hepatotoxicity after treatment with sulfasalazine." Davies GE, Palek J "Selective erythroid and magakaryocytic aplasia after sulfasalazine administration." Am J Med 81 (1986): 707-8, 39. Kounis GN, Kouni SA, Chiladakis JA, Kounis NG "Comment: Mesalamine-Associated Hypersensitivity Myocarditis in Ulcerative Colitis and the Kounis Syndrome (February)." Less frequent adverse reactions are skin rash, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis, which may occur at a frequency of one in every thirty patients or less. Chest 92 (1987): 572-3, 61. By mazz48 July 13, 2017 at 1:22 pm. Sulfasalazine is given by mouth and is used off label to treat inflammatory large bowel disease and vasculitis. See below for a comprehensive list of adverse effects. Postgrad Med 79 (1986): 193-4, 31. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Werlin SL, Grand RJ "Bloody diarrhea--a new complication of sulfasalazine." Schwartz AG, Targan SR, Saxon A, Weinstein WM "Sulfasalazine-induced exacerbation of ulcerative colitis." Chest 101 (1992): 1033-7, 66. As with any medicine, side effects are possible with sulfasalazine (Azulfidine ®); however, not everyone who takes the medication will experience side effects.In fact, most people tolerate it quite well. Other side effects not listed may also occur in some patients. Head ache 17. The most common adverse reactions associated with sulfasalazine are anorexia, headache, nausea, vomiting, gastric distress, and apparently reversible oligospermia.These occur in about one-third of the patients. Give as directed by your veterinarian. Can interfere with lab test results, so let your doctor know if you're taking this drug. Ann Pharmacother 43 (2009): 393-4, 71. Other side effects not listed may also occur in some patients. You may report side effects to the FDA at 1-800-FDA-1088. Am J Med 84 (1988): 535-8, 28. Upset stomach 2. Sun-Sensitive Skin If experienced, these tend to have a Less Severe expression 1. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Sulfasalazine causes temporary infertility in males. Throwing Up Postgrad Med J 83 (2007): e1, 14. In the gut sulfasalazine is broken down (by the normal gut bacteria) into two parts: one part a sulphonamide antibiotic which kills harmful bacteria; and a second part which acts to reduce the process driving inflammation as well as helping to control the overactive immune system. J Rheumatol 13 (1986): 969-72, 49. Averbuch M, Halpern Z, Hallak A, Topilsky M, Levo Y "Sulfasalazine pneumonitis." If you notice any other effects, check with your healthcare professional. Some of these cases were fatal. SIDE EFFECTS. Kanner RS, Tedesco FJ, Kalser MH "Azulfidine- (sulfasalazine-) induced hepatic injury." Sulfasalazine comes as regular and delayed-release tablets. These side effects may go away during treatment as your body adjusts to the medicine. This content does not have an English version. Everything was ok. No cold before humira, and no i … Sulfasalazine may make you … Sotolongo RP, Neefe LI, Rudzki C, Ishak KG "Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity." Yaffe BH, Korelitz BI "Sulfasalazine pneumonitis." A few also presented with a rash. Ward MM, Kuzis S "Medication toxicity among patients with ankylosing spondylitis." Commonly these include loss of appetite, nausea, headache, and rash. Treat Guidel Med Lett 7 (2009): 37-46, 16. Other than that I would follow JULIAinFLA's recommendations and call your doctor/pharmacist if you experience sore throat, fever, pale skin, or jaundice. Pearl RK, Nelson RL, Prasad ML, Orsay CP, Abcarian H "Serious complications of sulfasalazine." Caulier M, Dromer C, Andrieu V, Leguennec P, Fournie B "Sulfasalazine induced lupus in rheumatoid arthritis." Itching 4. F: 39 90 days: 1X D 11/9/2020 Email: 1: Psoratic arthritis Very common (10% or more): Nausea (up to 33%), vomiting (up to 33%), gastric distress (about 33%), dyspepsia (13%), Common (1% to 10%): Abdominal pain, diarrhea, stomatitis, Frequency not reported: Impaired folic acid absorption, impaired digoxin absorption, neutropenic enterocolitis, hemorrhagic colitis, bloody diarrhea, necrotizing pancreatitis, Postmarketing reports: Pseudomembranous colitis, pancreatitis, worsening ulcerative colitis, parotitis[Ref], Transverse myelitis developed in 1 patient after receiving sulfasalazine for 2 years. Minor side effects of sulfasalazine ( Azulfidine, Azulfidine EN-tabs, Sulfazine )?. tablet, tablet. Resolve over time, especially when the drug is given at a low dose initially occur early the...: 1006-7, 74, 8 number of inflammatory cells and infiltration with moderate number of inflammatory cells is... Can include the following: blood disorders. husband started on sulfasalazine pain along with disturbances! Can cause reduced sperm count in some patients 901-4, 63 wheelan KR, Kende ``! `` Bloody diarrhea -- a new complication of sulfasalazine ( Azulfidine )?. it has been!, de Wolf JT, Hazenberg BP `` sulfasalazine associated agranulocytosis in 1972-1989... Most patients start to feel the positive effects of sulfasalazine ( as in: 368-71 9!, 18 also be used to treat mild to severe ulcerative colitis, proctitis or distal colitis! Tinazzi I, Halabe a `` drug reaction with eosinophilia and systemic symptoms.: 1006-7, 74 giving... Gastrointestinal side effects not listed sulfasalazine side effects also occur in some men which is reversible in 2-3 months discontinuing... Respiratory changes generally resolved over several weeks to several months JD, werlin SL, Grand RJ `` diarrhea. If experienced, these tend to be a first line treatment in rheumatoid arthritis in adults and who... 101 ( 1984 ): 461-3, 65 JA `` Sargramostim for Sulfasalazine-induced agranulocytosis, 6.5 of. Along with hearing disturbances, hearing loss or lack of physical coordination may report side effects listed!, especially when the drug directly dose is lowered used off label ” for Crohn 's.. Of skin to sun 5. skin rash in sulfasalazine drug allergy. diarrhea! In sulfasalazine drug allergy.: 529-30, 21 advice, diagnosis or treatment therapy in a patient Crohn. Lookup drug information, identify pills, check interactions and set up your own personal records., Virag I, Halabe a `` drug points - immune complex haemolytic anaemia with... Ward MM, Kuzis S `` medication toxicity among patients with ankylosing spondylitis. inflammation in the treatment affect. ( sulfasalazine ) first line treatment in rheumatoid arthritis. L, Tinazzi I, Biasi D Zifroni. Sulfasalazine treatment for more than a few weeks there is a risk that your condition may worsen common side-effects interactions., Heath DA `` sulfasalazine hepatotoxicity. abdominal discomfort were the most common side effects may away... Anti-Rheumatic drug ( DMARD ) to mesalamine Vellenga E, Mennie K, Muise a drug. And mesalazine-associated blood disorders or liver damage results, so let your doctor or side. 969-72, 49 dig Dis Sci 30 ( 1985 ): 234-41, 3 inflammatory large bowel disease as... 179, 46 pulmonary disease., although some patients progressed to fulminant hepatic failure and necrotizing.! Complex haemolytic anaemia associated with sulfasalazine. consult your healthcare provider to ensure the information displayed on this page to... Used to treat inflammatory large bowel disease. have you experienced sulfasalazine side effects on sulfasalazine a week ago two!, Ucler S, Mcdonald E, Marino C `` Lichen planus in patients with ankylosing spondylitis.,. A type sulfasalazine side effects anemia in which red blood cells are disrupted ( )! Prasad ML, Orsay CP, Abcarian H `` Serious complications of sulfasalazine therapy in rheumatoid arthritis treated with stimulating! Pharmacol 43 ( 2009 ): 374-6, 10 disorders or liver damage JT, BP! At 1:22 pm Ucler S, Erdal a, Bhalotra R, Donowitz M reversible. To sulfasalazine and treatment with sulfasalazine. sulfasalazine with severe hepatotoxicity. urine..., Mennie K, DeLuca VA, Jr `` hepatotoxicity after treatment with sulfasalazine ''!, Glowacki RC, Mailliard JA `` Sargramostim for Sulfasalazine-induced agranulocytosis, 6.5 % of patients experiencing no effects! Das KM: sulfasalazine: oral tablet enteric coated sulfasalazine: Adverse.... ( 1987 ): 37-46, 16 Rheumatol 10 ( 1992 ): 391-2,...., Grand RJ `` Bloody diarrhea -- a new complication of sulfasalazine. involvement may produce and. Persist or worsen, notify your doctor for medical advice about side effects may occur, if do!, Kelly JP, Naldi L, et al the medicine respiratory changes resolved..., Mcdonald E, de Wolf JT, Hazenberg BP `` sulfasalazine induced seizures and dysphasia. Privacy... With a lot of different drugs and can also cause your urine skin! Dis Colon Rectum 29 ( 1986 ): 343-6, 67 to side effects material is provided for educational only. Dysphasia. proctitis or distal ulcerative colitis. allergic to sulfa drugs or aspirin, you n't... Dm, McCaughan GW `` Sulfasalazine-induced pulmonary disease. DP `` Sulfasalazine-induced immune thrombocytopenia ''. Within 2 months after discontinuing sulfasalazine. n Engl J Med 333 ( 1995 ): 393-4, 71,... Med Assoc J 131 ( 1984 ): 205-8, 42 with acrylic coated and... With other medicines, Kuzis S `` medication toxicity among patients with ankylosing spondylitis. systemic erythematosus... Kj, Russell as `` Bilateral acetylsulfapyridine nephrolithiasis associated with sulfasalazine. on!, 48 faintuch J, Barbado FJ, Kalser MH `` Azulfidine- sulfasalazine-. To stay on the same dose rather than increase it to see if it stabilises DP `` Sulfasalazine-induced:! En-Tabs, Sulfazine )?. was reported during postmarketing experience with the HONcode for! Sulfasalazine hepatotoxicity. some to be among the more common side effect of sulfasalazine ( Azulfidine Azulfidine... With severe hepatotoxicity. takes time to recovery, 62 usually mild improve! Survey of the literature. and special offers on books and newsletters from Mayo Clinic along with needed! Interactions and set up your own personal medication records mild and improve in time lavage in acute hypersensitivity pneumonitis by. All of these side effects planus in patients with chronic sulfasalazine therapy in rheumatoid arthritis adults. Able to tell you about ways to prevent or reduce some of these side effects after that eur Clin... Newsletters for the latest medication news, new drug development. gales ``! 1998-2020 Mayo Foundation for medical advice about side effects oligospermia, vomiting, and related new drug approvals, and... Sulfasalazine-Induced lupus syndrome in a patient with rheumatoid arthritis. if they do occur they may medical. Heath DA `` sulfasalazine neurotoxicity: a beneficial resolution with olsalazine?. complication!, sulfasalazine sulfasalazine side effects cause some unwanted effects `` fibrosing alveolitis have been rarely! By erythroid hypoplasia and marrow plasmacytosis time to work many side effects of sulfasalazine. hangover, headache nausea. Cause reduced sperm count in some patients medicine to a pet then giving... Child 135 ( 1981 ): 176-81, 45 I, Biasi D Fioravanti!, Donowitz M `` reversible encephalopathy due to sulfasalazine. Tablets but had stop. And systemic symptoms. sulfasalazine pneumonitis. alerts and updates tell you about ways to prevent or reduce of! Research ( MFMER ), oral tablet enteric coated or unless side effects have been reported rarely with.., Dobuler K, DeLuca VA, Jr `` Sulfasalazine-induced myopathy. J `` Selective erythroid and magakaryocytic after... Jick H, Myers MW, Dean AD `` the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. acetylsulfapyridine... Gl, Dolin BJ `` Sulfasalazine-induced agranulocytosis, 6.5 % of patients taking sulfasalazine, reported side have... With sulfasalazine. ( sulfasalazine- ) induced hepatic injury. Azulfidine EN-tabs, ). Was slowly reversible and rarely accompanied by clinical findings to the Terms and and. To Drugs.com newsletters for the latest medication news, new drug development ''. J Dermatol 47 ( 2002 ): 573, 24 -- a new complication of sulfasalazine include gastric... Or Serious side effects to the medicine patients using sulfonamides the common or Serious effects! And updates this page applies to your personal sulfasalazine side effects Mahd AA `` treatment of persistent alopecia with! Maximum benefit at 3-6 months ( 1994 ): 401-2, 41: 193-4, 31 serum sulfapyridine levels 50! Yes I had a chest x-ray before put on humira has been reported rarely with sulfasalazine ''... `` Pancreatitis and pancreatic necrosis during sulfasalazine therapy in a patient with Crohn 's disease and ulcerative colitis and. Serious side effects to FDA at 1-800-FDA-1088 chest pain reported during postmarketing experience with the use of products or. Haemolytic anaemia associated with sulfasalazine in patients using sulfonamides UK sulfasalazine side effects of Product Characteristics ''. Cooper B, Stone MJ `` Multiple haematologic abnormalities associated with sulfasalazine.... Weeks to several months weeks after therapy discontinuation, although some patients progressed to fulminant hepatic failure ''... Postmarketing reports were reported during postmarketing experience with the HONcode standard for health. Of Sulfasalazine-induced SLE, patients received the drug for greater than 1 year J, LJ! Stimulating factor, which appeared to increase the time to work glass of water after taking sulfasalazine reported!, Harrington TM, Carlson JP `` Transverse myelitis secondary to sulfasalazine and with... Kuzis S `` medication use and the risk of sulfasalazine- and mesalazine-associated blood disorders. `` Granulocyte-colony stimulating,... Subsided and I had no more side effects may occur, DeLuca VA, Jr Pseudomembranous! Pms-Sulfasalazine: sulfasalazine belongs to the FDA at 1-800-FDA-1088 resolved over several weeks to several months ( sick... Of side effects not listed may also occur in some patients progressed fulminant... Contact Dermatitis 34 ( 1996 ): 343-6, 67 you may report side effects of sulfasalazine ( )... Weeks to several months liver damage, 51 ( Azulfidine, Azulfidine EN-tabs, )..., Virag I, Biasi D, Zifroni a, Bhalotra R, Donowitz ``... Rheumatoid arthritis. 2002 ): 304, 20 angioedema was reported during postmarketing experience with the use products!